川参通注射治疗前列腺增生症的临床和实验研究

Clinical and Experimental Study of Benign Prostatic Hyperplasia with Intraglandular Injection of Chuan Shen Tong(川参通)

我院用中药川参通注射液注射治疗前列腺增生症１０３８例，总有效率９６％。尿流率峰值和平均值治疗后分别提高１８．０％（Ｐ＞０．０５）、４１．８％（Ｐ＜０．０１）；经腹和直肠超声测量前列腺体积，分别比治疗前缩小０．５１ｃｍ（Ｐ＞０．０５）、０．４０ｃｍ（Ｐ＜０．０１）；剩余尿量均值减少６０．５ｍｌ（Ｐ＜０．０１）；症状改善，效果满意。动物实验表明，川参通对丙酸睾丸酮所致的小鼠前列腺增生，有明显的治疗作用。病理证实增生的腺体缩小。实验犬的前列腺组织定量分析结果，治疗后主质缩小２６．８％、间质缩小４．５％，总体积缩小３１．３％。为临床应用川参通注射液治疗前列腺增生症提供了可靠依据。

cases of benign prostatic hyperplasia(BPH)were treated by injection of Chuan Shen Tong(CST),a Chinese herbal medicine,into the prostate gland.At the end of treatment the effective rate was 96%.After the treatment the BPH with urodynamic measurement was studied and it was found that the peak flow rate and mean flow rate increased 18% and 41.8% respectively.Transabdominal and transrectal ultrasonographies were used to measure the shrinkage of prostate's size after the injection treatment to be 0.51 and 0.4 cm(mean diameter)respectively.Animal model of BPH was established by the testosterone propionate.The prostatic weight and prostatic index was measured in mice after the injection of CST,it significantly decreased compared with that of the control (P<0.01).The pathological findings:The hyperplastic papillae disappeared and the body of prostate markedly shrank in size.Experiment dogs has been carried out for the prostate quantitative analysis.The result revealed that the prostate parenchyma and intercellular substance shrank to 26.8% and 4.5% respectively.