豨莶通栓丸治疗脑血栓的临床与实验研究

Clinical Effect and Experimental Study of Xijian Tongshuan Pill(豨莶通栓丸) on Cerebral Thrombas

采用 莶通栓丸治疗脑血栓患者７０例，并与以低分子右旋糖酐加维脑路通（对照Ａ组）和环扁桃酯胶囊（对照Ｂ组）治疗进行前后对比观察血液流变学及头部ＣＴ变化比较。结果表明，有效率治疗组与对照Ａ组和Ｂ组比较有显著性差异（Ｐ＜０．０１），其血液流变学及头部ＣＴ改变也有显著性差异（Ｐ＜０．０１）。药理实验证实莶通栓丸能明显抑制血小板聚集，降低全血粘度，抗缺氧，增加脑血流量。该药无毒副作用。

Xijian Tongshuan pill(XJTS),consisted of Siegesberkia orientalic,Moschas moschtfena,Hirudo nitoonica,Pmnus Persicae, Carthamus tinctomis,Ligusticum wallichi, Panax notoginseng,Angelica Sinensis,Boreeolum, etc,were used in treating 70 patients with cerebral thrombosis.The marked effective rate was 82.9%,total effective rate was 96.7%.In control group A,Dextranum and Venoruton were used,in control group B cyclandelate capsule were used.The marked effective rate was 61.7% and 61.1% respectively,the total effective rate was 81.7% and 83.3%.The differences were significant(P<0.01).The improvement of blood rheology and CT of brain were also sigmficant(P<0.01).The experiment proved that XJTS pill could inhibit and delay the thrombosis of rabbit,inhibit the platelet aggregation.Acute and subacute toxicity tests proved that XJTS pill was safe and effective.