摘要
将95例使用高剂量顺铂治疗肿瘤患者随机分为中药预防组和水化对照组,用多项指标观察不同药物对肾功能的影响。结果表明中药组治疗后血BUN、血Cr、血β2-m、尿NAG下降,两组疗后的BUN、Cr差异有显著性,中药健脾益气利水汤预防高剂量顺铂肾毒性疗效优于水化组。用此方治疗化疗性肾衰40例(44例次),总有效率为93.18%,治疗前后BUN、Cr有非常显著差异。临床研究表明中药健脾益气利水汤具有预防和治疗化疗肾毒性的作用。
cases of cancer patients were treated with large dose of Cisplatinum.They were randomly divided into treated group with Chinese medicinal herbs (49 cases) and control group with hydration treatment (46 cases). Multiple indexes were selected to observe effect on renal function.The result showed that the level of blood urea nitrogen (BUN), creatnine (Cr), β2 microglobulin (β2-MG), urea N-acetyl-β-glucosaminidase (NAG) of treated group lowered. After treatment the difference of BUN, Cr between the two groups was significant(P<0.05). It suggested that Jian-Pi Yi-Qi Li-Shui Decoction (JPYQLSD) was superior to hydration group in preventing the large dose of Cisplatinum induced nephrotoxicity. It was also used to treat 44 cases-times of chemotherapy caused renal failure. The total effect rate is 93.18%. The difference of the level of BUN, Cr between before and after treatment was very significant (P<0.01). It is proved that JPYQLSD has good effect in treating chemotherapy caused renal failure.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
1994年第6期331-333,共3页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
顺铂
肾功能衰竭
中西医结合
治疗
Jian-Pi Yi-Qi Li-Shui Decoction, Cisplatinum, renal failure