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地塞米松对脓毒症大鼠肝脏Toll样受体4的干预作用 被引量：1

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作者 李强 洪玉才 唐建中 徐鑫荣 王勇 苗毅
机构地区 南京医科大学第一附属医院ICU 浙江大学附属第二医院急诊科 南京医科大学第一附属医院普外科
出处 《中华急诊医学杂志》 CAS CSCD 2005年第6期485-487,共3页 Chinese Journal of Emergency Medicine
基金 南京医科大学科技发展基金资助项目(NY03026)
关键词 TOLL样受体4 脓毒症 干预作用 大鼠肝脏 地塞米松 receptor 信号转导途径 革兰氏阴性菌 盲肠结扎穿孔 革兰阴性菌 研究发现 致病过程 受体分子 跨膜蛋白 TLR4 家族成员 免疫应答 病理状态 内毒素 厌氧菌 机体 器官
分类号 R631.3 [医药卫生—外科学]
  • 相关文献

参考文献11

  • 1Muzio M, Polentarutti N , Bosisio D , et al. Toll-like receptors : a growing family of immune receptors that are differentially expressed and regulated by different leukocytes . J Leukc Biol , 2000 , 67(4) : 450.
  • 2Hoshino K, Takeuchi O , Kawai T , et al . Cutting edge : Toll-like receptor 4 ( TLR4 ) dificient mice are hyporesponsive to lipopolysaccharide : evidence for TLR4 as the LPS gene product . J immunol , 1999 , 162 (7) : 3749 - 3752.
  • 3Chaudry IH , Wichterman KA , Baue AE. Effect of sepsis on tissue adenine nucleotide levels. Surgery, 1979, 85 (2) : 205-211.
  • 4Nowak M , Gaines GC , Rosenberg J , et al. LPS induced liver injury in D-galactosmine sensitized mice requires secreted TNF-alpha and theTNF-p55 receptor. Am J Physiol Regul Integr Comp Physiol , 2000 , 278(5) : 1202-1209.
  • 5Su GL , Klein RD , Aminlari A , et al. Kupffer cell activation by lipopolysacchafide in rats : role for lipopolysacccharide binding protein and toll-like receptor 4. Hepatology , 2000 , 31 (4) : 932-936.
  • 6Yang H , Young DW, Gusovsky D , et al. Cellular events mediated by lipopolysaecharide stimulated toll-like receptor 4 MD22 is required for activation of mitogen activated protein kinases and Elk-l. Bio Chem,2000, 275 (27) : 20861 - 20866.
  • 7Chow JC, Young DW, Golenbock DT, et al. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J BiolChem.1999, 274 (26) : 10689 - 10692.
  • 8Wolfs TG, Buurman WA , van Schadewijk A , et al. In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells : IFN-gamma and TNF-alpha mediated up-regulation during inflammation . J Immunol ,2002 , 168 (16) : 1286 - 1292.
  • 9鄢小建,姚咏明,董宁,于燕,张立天,盛志勇.腹腔感染所致多器官损害与Toll样受体2基因表达的关系[J].中华实验外科杂志,2003,20(1):36-38. 被引量：8
  • 10Nattermann J , Du X, Wei Y, et al . Endotoxin-mimetie effect of antibodies against Toll-like receptor 4. J Endotoxin Res , 2000 , 6(3) : 257 - 264.

二级参考文献10

  • 1黎君友,于燕,郝军,晋桦,许惠君.分光光度法测定血和小肠组织二胺氧化酶活性[J].氨基酸和生物资源,1996,18(4):28-30. 被引量：202
  • 2Hoshino K, Takeuchi O, Kawai T, et al. Cutting edge: Toll-like receptor 4 (TLR4) dificient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the LPS gene product. J immunol,1999, 162: 3749-3752.
  • 3Schmidt J, Lewandrowsi K, Warshaw A. Morphometric charateristics and homogeneity of a new model of acute panctreatitis in the rat. Int J Pancreatol, 1992, 12: 41-51.
  • 4Chen XL, Valente JF, Alexander JW. The effect of sennosides on bacterial translocation and survival in a model of acute hemorrhagic pancreatitis. Pancreas, 1999, 18: 39-46.
  • 5Wang XP, Wang BX, Wu JX. Pancreatitis-associatocl protein-Ⅰ mRNA expression in mouse pancreas is upregulated by lipopolysaccharide independent of cerulein-pancreatitis. J Gastroenterol Hepatol, 2001, 6:79-86.
  • 6Ogawa M. Acute pancreatitis and cytokines: "second attack" by septic complication leads to organ failure. Pancreas, 1998, 16: 312-315.
  • 7Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophilla Toll protein signals activation of adaptive immunity.Nature, 1997, 249: 1431-1433.
  • 8Pohorak A, He X, Smirnoval, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science, 1998,282: 2085-2088.
  • 9Nattermann J, Du X, Wei Y, et al. Endotoxin-mimetic effect of antibodies against Ton-like receptor 4. J Endotoxin Res, 2000, 6: 257-264.
  • 10李红云,姚咏明,盛志勇.Toll样受体与脓毒症的研究进展[J].中华烧伤杂志,2002,18(5):314-317. 被引量：19

共引文献11

同被引文献10

引证文献1

二级引证文献1

中华急诊医学杂志
2005年 第6期

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