期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肺炎衣原体感染免疫反应的研究进展 被引量：3

The immune response to Chlamydia pneumoniae infection
下载PDF
导出
摘要 肺炎衣原体(Cpn)是一种常见的人类呼吸道致病菌,常引起急性呼吸道感染及动脉硬化、心肌梗死等多种相关性疾病。感染Cpn后多呈慢性经过,可诱发以Th1型细胞免疫反应为主的特异性免疫。同时,体液免疫及有Toll样受体参与的非特异性免疫也在病原菌的清除中起辅助作用。作者就机体感染Cpn后免疫反应的进展作一综述。 Chlamydia pneumoniae(Cpn) is one of the most common pathogens causing human respiratory tract infection.They cause acute respiratory tract infection,atherosclerosis and many other diseases. Cpn infection often recur or remain persistent,which may induce Th1-type response.At the same time,antibody-mediated immune and Toll like receptor play an auxiliary role.In this review,the author summarized advances in the immune response to Chlamydia pneumoniae infection.
作者 邵宏涛 施毅
机构地区 南京大学医学院临床医院(南京军区南京总医院)呼吸科
出处 《医学研究生学报》 CAS 2005年第6期550-553,558,共5页 Journal of Medical Postgraduates
基金 江苏省应用基础研究自然科学基金资助项目(批准号:BJ98065)
关键词 肺炎衣原体 免疫反应 感染 Chlamydia pneumoniae Immune response Infection
分类号 R563.1 [医药卫生—呼吸系统]
  • 相关文献

参考文献28

  • 1印洁,施毅,周晓军,孟奎,朱美英.肺炎衣原体感染小鼠肺组织免疫组化表现[J].医学研究生学报,2003,16(4):253-255. 被引量：5
  • 2Yang H, Young DW, Gusovsky F et al. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4[J]. J Biol Chem, 2000,275(3):20861-20866.
  • 3Huittinen T, Leinonen M, Tenkanen L et al.Autoimmunity to human heat shock protein 60, Chlamydia pneumoniae infection, and inflammation in predicting coronary risk[J]. Arterioscler Thromb Vasc Biol, 2002, 22(3):431-437.
  • 4Kol A, Lichtman AH, Finberg RW et al.Heat shock protein (HSP) 60 activates the innate immune response: CD14 is an essential receptor for CHSP60 activation of mononuclear cells[J]. J Immunol, 2000, 164(1):7-13.
  • 5Donath B , Fischer C ,Sharon P et al. Chlamydia pneumoniae activates IKK/IκB-mediated signaling, which is inhibited by 4-HNE and following primary exposure[J]. Atherosvlerosis, 2002, 165(1):79-88.
  • 6Erkkila L, Laitinen K, Laurila A et al. Expermental Chlamydia pneumoniae infection in NIH/S mice:effect of reinnoculation with Chlamydial or cell preparation on culture, PCR and histoligical findings of lung tissue[J]. Vaccine, 2002, 20(17-18) :2318-2324.
  • 7Rupp J, Droemann D, Goldmann T. Alveolar epithelial cells type Ⅱ are major target cells for Chlamydia pneumoniae in chronic but not in acute respiratory infection[J]. FEMS Immunol Med Microbiol, 2004,41(3):197-203.
  • 8Betson F, Sueur JM, Orfila J. Anti- Chlamydia pneumoniae heat shock protein 10 antibodies in asthmatic adults[J]. FEMS Immunol Med Microbiol, 2003, 35(2):107-111.
  • 9Stephers RS ,Lammel CJ. Chlamydia outer membrane protein discovery using genomics[J]. Current Opinion Microbiol, 2001, 4(1):16-20.
  • 10Rottenberg ME, Gigliotti-Rothfuchs A,Wigzell H. The role of IFN-g in the outcome of chlamydial infection[J]. Current Opinion Immunol, 2002,14(4):444-451.

二级参考文献10

  • 1倪安平,李永哲.抗肺炎衣原体种特异性单抗制备及初步鉴定[J].中华医学杂志,1994,74(7):416-419. 被引量：4
  • 2Murdin AD, Dunn P, Sodoyer R, et al. Use of a mouse lung challenge model to identify antigens protective against Chlamydia pneumoniae lung infection[J]. J Infect Dis,2000,181:s544-s551.
  • 3Yang ZP, Kuo CC, Grayston JT. A mouse model of Chlamydia pneumoniae strain TWAR pneumonitis[J]. Infect Immu,1993,61:2037-2040.
  • 4Naas J,Gnarpe JA.Demonstration of clinical pneumoniae in tissue by immunohistochemistry[J].APMIS,1999,107(9):882-886.
  • 5Moazed TC, Kuo CC, Patton DL, et al. Experimental rabbit models of Chlamydia pneumoniae infection[J]. Am J Pathol,1996,148:667-676.
  • 6Cho-chou Kuo,Allan Shor,Lee Ann Campbell,et al.Demonstration of Chlamydia pneumoniae in atherosclerotic lesions of coronary arteries[J].JID,1993,167:841-849.
  • 7Grayston JT, Campbell LA, Kuo CC, et al. A new respiratory tract pathogen:Chlamydia pneumoniae strain TWAR[J]. J Infect Dis,1990, 161:618-625.
  • 8夏锡荣,宋勇,康晓明,冯根宝,胡兰萍.肺炎衣原体急性呼吸道感染的临床研究[J].中华结核和呼吸杂志,1998,21(5):280-283. 被引量：40
  • 9施毅,印洁.肺炎衣原体呼吸道感染发病机制研究进展[J].国外医学（呼吸系统分册）,2000,20(2):88-90. 被引量：13
  • 10施毅,印洁,詹化文,冯根宝,苏欣,夏锡荣,周晓军,申萍,胡兰萍,朱美英.肺炎衣原体肺炎小鼠模型的建立与实验研究[J].中华结核和呼吸杂志,2001,24(10):592-595. 被引量：12

共引文献4

同被引文献40

引证文献3

二级引证文献10

医学研究生学报
2005年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部