疔毒丸对胃肠平滑肌电活动与胃肠运动效应的影响

Effects of Dingduwan on Electric Activities of Gastrointestinal Smooth Muscle and Effect of Gastrointestinal Motility

采用改进的整体同步记录方法，研究疔毒丸对胃肠平滑肌电活动及胃肠运动效应的影响。大鼠以３．５ｇ／ｋｇ灌胃可显著增加胃肠电慢波平均振幅、胃肠运动总振幅、肠电慢波频率和肠运动频率（Ｐ＜０．０５），但对胃电慢波频率和胃运动频率无明显影响（Ｐ＞０．０５）。小鼠以５．２ｇ／ｋｇ灌胃可显著促进肠套叠还纳作用。结果显示疔毒丸可增强肠电活动和肠运动，其程度明显大于对胃的作用。

Dingduwan(DDW) is a Chinese herbal medicine.Method of modified synchronous recording was used to study the electric activities of gastrointestinal(GI) smooth muscle and the effect of GI motility treated by DDW.A dosage of 3.5g/kg for ingestion in rats markedly increased the average amplitude of GI slow wave,the total amplitude of GI motion,the rateof GI slow wave and intestinal motion(P<0.05),but it had no significant effects on the frequency of gastroelectric slow wave and gastric motility(P<0.05).DDW in the dosage of 5.2g/kg for ingestion markedly promoted the recovery of intestinal intussusception in mice(P>0.05).The results showed that DDW markedly increased the intestinal electricity and motility more than that of stomach.