肾移植患者高尿酸血症与痛风的研究进展

Hyperuricemia and gout in renal transplant recipients

高尿酸血症在肾移植患者中较为常见,在接受环孢素A(CsA)治疗的患者中发病率更高。尿酸升高的原因多与药物治疗时间的长短有关,与剂量、血药浓度、血肌酐水平无明显相关性。肾移植患者痛风的发生率较低,其确切的病因目前尚不清楚。肾移植术后高尿酸血症和痛风的处理,目前尚有争议,作者对肾移植患者高尿酸血症和痛风作一综述。

Hyperuricemia, unlike clinical gout, is common in renal transplant patients,especially in cyclosporine treated renal allograft recipients.The high prevalence of hyperuricemia is related to prolonged exposure to cyclosporine rather than to its dose or serum concentration. Serum creatinine levels do not show significant correlation with hyperuricemia, The reason why the low incidence of gout in renal transplant patients is not yet clear, it is not clear how to treat them, therefore the hyperuricemia and gout in renal transplant recipients is reviewed.