猴头菇多糖的免疫调节作用

Immunomodulatory Function of Polysaccharide of Hericium erinaceus

应用四甲基偶氮唑盐（ＭＴＴ）比色分析法检测细胞的代谢活性及增殖反应。实验结果显示，猴头菇多糖对由刀豆球蛋白（ＣｏｎＡ）活化的小鼠胸腺细胞（前Ｔ细胞）有较强的促进增殖的作用，其ＯＤ值为单独使用刀豆球蛋白Ａ的２倍以上；在脾脏淋巴细胞培养中，单独使用猴头菇多糖可以显著地促进细胞的增殖，其作用较对照组明显。对脂多糖（ＬＰＳ）刺激的Ｂ细胞也有协同作用。

Hericium erinaceus is a Chinese herbal medicine. The Apollo oral liquid contains polysaccharide of H.erinaceus(PHE).The effects of PHE on proliferation of mice T and B lymphocytes were studied.Results showed that(1) 3-fold proliferation of thymocytes was demonstrated when PHE were administrated with Con A than Con A alone.Such effect on thymocyte was not observed when PHE was used alone.(2)Proliferation of spleen lymphocytes was also stimulated when PHE were taken together with lipopolysaccharide,which was 50% and 3 times stronger than that of using lipopolysaccharide and PHE alone respectively.