脊髓灰质炎后遗症患者血清HBV感染状况调查

Serologic Investigation of HBV in Patients with Poliomylitis Lameness

目的探讨脊髓灰质炎(脊灰)病毒感染后对乙型肝炎病毒(HBV)感染的影响。方法用ELISA法作二项HBV血清学检测(HBsAg和抗HBs),调查1998～2002年,收住的107例来自农村地区的脊灰后遗症患者,并设对照组进行对照分析。结果107名脊髓灰质炎后遗症患者HBV血清学调查,结果HBsAg和抗HBs阳性率(2.8%;15%)分别显著低于生活在农村的对照组1(15.9%,P<0.01;26.6%,P<0.05)和生活在城市的对照组2(8.9%,P<0.05:36.9%,P<0.01)。两对照组间也存在显著性差异(P<0.05)。同时发现农村和城市居住者,乙肝疫苗和脊灰疫苗接种有很大差异。结论我们认为脊灰感染后和脊灰疫苗接种可能干扰HBV感染。

Objective To explore the effect to HBV infection after Poliolameness infection. Methods HBV serology markers (HBsAg and Anti-HBs) were detected in total 107 hospitalized cases with Poliolameness in Xinjiang rural area from 1998 to 2002. Results This survery provides serologic investigation resurlts of HBV in 107 Patients wi th Poliolameness.The results showed HBsAg and anti -HBs positive rates (2.8%;15 . 0% ) and were significantly lower than those of the control group 1 (15.9%,P<0 .01;26.6%,P<0.05) from rural area and group 2 (8.9%,P<0.05;36.9%,P<0.01) f rom city.The HBsAg positive rates of the control group 1 were significantly high er t han those of group 2 (P<0.05).Whereas Anti -HBs positive rates in control g roup 2 were significantly higher than those in control group 1 (P<0.05 ).The v accination rate of poliovaccine and HBV vaccine of patients from rural area wer e significantly lower than those of Patients from city.Conclusion It may suggest that the Poliomylitis and oral poliovaccine interfere with HBV infection