脑心速通治疗急性脑梗塞的临床研究

Clinical Study of Naoxin Sutong in Treating Patients with Acute Cerebral lnfarction

应用脑心速通对４１例急性脑梗塞患者进行临床观察，并动态观察患者的血清丙二醛（ＭＤＡ）含量、治疗前后血脂、血液流变学等指标。选用川芎嗪作为对照药。结果：脑心速通组的神经缺损的进步分数高于川芎嗪组（Ｐ＜０．０５）。脑心速通和川芎嗪组ＭＤＡ含量明显高于健康人组（Ｐ＜０．０１）；经脑心速通治疗后患者ＭＤＡ含量明显下降，于治疗３周后接近健康人水平（Ｐ＞０．０５），川芎嗪组血清ＭＤＡ含量在治疗后无明显变化（Ｐ＞０．０５）。患者血液流变学等指标及血脂在脑心速通治疗后亦有明显改善。提示：脑心速通对急性脑梗塞的疗效优于川芎嗪，机制是其具有清除自由基、减轻脑缺血－再灌流损伤等作用。

It was showen that the cerebral ischemia-reperfusion produced free radicals are the main factor that causes irreversible cerebral injury.The mechanism of Naoxin Sutong (NXST)treated acute cerebral infarction was elucidated.It is compared with Ligustrazine(LT),which has been proved to be an effective drug for cerebral infarction. The curative effect and the changes of serum malondialdehyde(MDA) levels,blood rheology,blood lipid,etc. of 41 patients with acute cerebral infarction within 3 days, who were confirmed by CT. The therapeutic result showed that after 4 weeks of treatment the points of progress for central nervous system deficit scoring of NXST and LT group were 10.67±5.02 and 6.85±4.49 respectively.The difference between these two groups was significant.MDA levels of the patients and the healthy subjects were 6.46±1.70 and 3.87±0.67 nmol/ml respectively,the difference was also significant(P<0.01) . After 2 weeks of treatment,MDA content of NXST was less than before(P<0.05).However the level of LT group did not reduce,while after 3 weeks of treatment,MDA content of NXST group was 4.34 nmol/ml.It was much less than that of LT group and approached that of healthy subjects. Results also showed that blood rheology improved,blood lipid reduced after NXST treatment.All these indicated that the effect of NXST in treating acute cerebral infarction was good,and the mechanism as that NXST could scavenge free radicals,ameliorate cerebral ischemia-reperfusion injury, improve blood rheology and reduce blood lipid.