脾虚泄泻患者红细胞免疫功能的临床研究

Study on Erythrocytic Immune Function in Diarrhea Patients with Spleen Deficiency

本研究按泄泻与否将４０例脾虚证患者分为泄泻和非泄泻组，并设２０例健康对照组，以观察脾虚泄泻患者红细胞免疫功能的变化。结果表明，脾虚泄泻组的红细胞Ｃ３ｂ受体花环率（ＲＢＣ－Ｃ３ｂ－ＲＲ）显著低于脾虚非泄泻组和健康对照组（Ｐ＜０．０１）；脾虚泄泻组的红细胞免疫复合物花环率（ＲＢＣ－ＩＣ－Ｒ）显著高于脾虚非泄泻组和康对照组（Ｐ＜０．０１）；而且Ｃ３ｂ－ＲＲ与木糖吸收率、红细胞数、血红蛋白、血浆白蛋白等呈显著正相关，ＩＣ－Ｒ与上述指标呈显著负相关（Ｐ＜０．０１）。提示脾虚患者小肠吸收功能障碍所致的贫血、低蛋白血症使红细胞Ｃ３ｂ受体数量减少或损伤或活性下降，导致红细胞免疫功能降低，脾虚泄泻患者病变程度较重，故其红细胞免疫功能降低也较明显。

The erythrocytic immune function of 40 cases of patients with Spleen Deficiency(SD) and 20 cases of the normal control group were observed, and the former were subdivide into diarrhea group and non-diarrhea group.The results showed that the rosette rate of red cell C3b receptor(C3b-RR)in the SD patients was significantly lower than that of normal group and the rosette rate of red cell immune complex(IC-R) was significantly higher than that of normal group(P<0.01);the C3b-RR in the diarrhea group was markedly lower than the non-diarrhea group,tce IC-R in the diarrhea group was markedly higher than the non-diarrh-ea group(P<0.01),C3b-RR and IC-R correlated positively or negatively to the absorptivity of D-xylose henioglobin,red blood cell and plasma albumin (P<0.01).The results pointed out that the mechanism for the reduction of erythrocytic immune function was that the malnutrition in SD patients lowered the C3b receptors or damaged them or reduced their activity.The degree of malabsorption and systemic dysfunction in the diarrhea group was more serious,the erythrocytic immune function in the SD patient was lower.