利多卡因和黄芪对心室晚电位的干预作用

Intervention of Lidocaine and Astragalus membranaceus on Ventricular Late Potentials

对３８例体表信号平均心电图（ＳＡＥＣＧ）检测为心室晚电位阳性的患者，分别予利多卡因静脉注射（１６例）或黄芪总甙注射液静脉滴注（２２例），每日１次，连续用２周。结果显示：利多卡因组２例（１２．５％）患者ＳＡＥＣＧ转为正常，但治疗前后平均ＳＡＥＣＧ指标无显著改变；黄芪组３例（１３．６％）患者ＳＡＥＣＧ转为正常，平均综合导联ＱＲＳ时限、ＬＡＳ显著缩短（Ｐ＜０．００１），ＲＭＳ４０增大（Ｐ＜０．０５），提示晚电位时限缩短。

and 22 patients with positive ventricular late potentials (LP) recorded on signal-averaged electrocardiograms (SAECG) were treated with lidocaine 100 mg iv.or Astragalus membranaceus 24 g iv. drip for 2 weeks respectively. As a result, the SAECGs of 2(12.5%) and 3 (l3.6%) of them normalized respectively. Compared with baseline,there were no significant changes in average HFQRSD, LAS and RMS 40 after treatment of lidocaine. HFQRSD and LAS were shortened significantly 115.9±29.9 vs 125.1±29.4ms(p<0.001): and 44.8±15.4 vs 52.8±15.4ms (P<0.001), and RMS 40 was enlarged 20.0±18.6 vs 12.8±19.0μV (P< 0.05) only after treatment of Astragalus membranaceus. It suggested that the duration of LP was shortened.