芍药甘草汤对顺铂所致的大鼠小肠电活动改变的影响

Effects of Paeonia-Glycyrrhiza Decoction on Changes Induced by Cisplatin in Rats

在大鼠小肠浆膜面埋植铂丝双极电极，以移行性综合肌电（ＭＭＣ）为指标，观察芍药甘草汤对顺铂所引致的大鼠小肠电活动改变的影响。静脉注入顺铂后，ＭＭＣ活动改变，其周期持续时间与正常ＭＭＣ周期持续时间相比明显缩短（Ｐ＜０．０５），而Ⅲ相持续时间与正常Ⅲ相持续时间比较显著延长（Ｐ＜０．０１）。口服芍药甘草汤后，静脉注入顺铂不再引致ＭＭＣ活动的改变。结果提示：芍药甘草汤对顺铂所引致的ＭＭＣ改变有明显的纠正作用，这可能是其制止顺铂所引致的大鼠腹泻的原因之一。

In order to study the effects of Paeonia-Glycyrrhiza decoction(PGD)on the changes induced by cisplatin in rats, platinum-wire bipolar electrodes were inserted into the serosal membrane of the small intestine and migrating myoelectric complex(MMC)was used as index. After intravenous injection of cisplatin at dosis of 4 mg/kg,the duration of the MMC cycles was significantly shorter than that of normal MMC cycles(P<0.05) while the duration of phase Ⅲ was remarkably prolonged comparing with that of normal phase Ⅲ(P<0.01) with latent period of 53.2±20.4minutes.Taking PGD orally,cisplation no longer induced the changes of MMC. The results suggest that PGD has marked adjusting effects on the changes of MMC induced by cisplatin.This might be one of the causes of PGD in relieving diarrhea induced by cisplation in rats.