生脉散对急性心肌梗塞患者的抗脂质过氧化作用

Effect of Sheng Mai San on Lipid Peroxidation in Acute Myocardial Infarction Patients

本文探讨了３０例心绞痛和６８例急性心肌梗塞（ＡＭＩ）患者与脂质过氧化损伤的关系，并观察了中药生脉散颗粒剂对ＡＭＩ患者的抗脂质过氧化作用。发现冠心病（ＣＨＤ）患者较健康人血中超氧化物歧化酶（ＳＯＤ），谷胱甘肽过氧化物酶（ＧＳＨ－Ｐｘ）活性明显降低，而丙二醛（ＭＤＡ）显著升高（Ｐ＜０．００１）。当给ＡＭＩ患者口服生脉散颗粒剂９ｇ／ｄ２周，血中ＳＯＤ和ＧＳＨ－Ｐｘ明显升高，ＭＤＡ显著降低（Ｐ＜０．０５）；给药４周则前者进一步升高，后者更为降低（Ｐ＜０．００１，Ｐ＜０．０１），而ＡＭＩ对照组之变化无显著性差异（ｐ＞０．０５）。结果表明：ＣＨＤ与自由基（ＦＲ）触发的脂质过氧化损伤有关；生脉散是一种有效的自由基清除剂，具有抗脂质过氧化作用。用生脉散防治ＣＨＤ有重要临床意义。

The effect of Sheng Mai San(SMS) on the coronary heart disease(CHD) patients (30 angina pectoris and 68 acute myocardial infartion, AMI) and its peroxidation damage was studied. It was shown that the activities of superoxide dismutase(SOD) and glutathione peroxidase(GSH-Px) in blood were decreased and the content of malondialdehyde(MDA) in plasma was increased in CHD patients in comparison with the healthy controls(P<0.001). When SMS was orally administered in 38 AMI patients, both SOD and GSH-Px activities were increased and the level of MDA decreased (P< 0.05), and these changes were even more significant when SMS was further ingested for another two weeks(P<0.001). At the same time, it was found that the changes of SOD, GSH-Px and MDA in the control group(30 AMI patients not taking SMS) were not significantly different(P>0.05). It could be assumed that the pathogenesis of CHD is associated with free redical(FR) triggering a chain reaction of the lipid peroxidation, and that SMS is acting as an effective free radical scavenger, which would ameliorate the lipid peroxidation damage. Thus, SMS could be administered in the prevention and the treatment of CHD.