先天性巨细胞病毒感染的围生儿预后

Prognosis of congenital cytomegalovirus infection

目的探讨先天性巨细胞病毒(HCMV)感染围生儿的预后。方法1996年1月至2004年8月,中山大学附属二院对HCMV活动性感染孕妇的23例先天感染儿及35例非感染儿,于出生时至8岁进行体格和神经系统发育的随访。1、6个月时应用聚合酶链反应(PCR)检测尿HCMVDNA。结果HCMV先天感染儿畸形、发育商(DQ)落后、听力(BAEP)异常率显著高于非先天感染儿(P<0.05)。结论先天性HCMV感染可能导致胎儿畸形,并对智力及听力有远期影响。应加强围生期管理,减少先天感染儿出生,随访感染儿并及早干预。

Objective To study the effects of congenital human cytomegalovirus (HCMV)infection on development of fetuses and children. Methods 58 neonates with mothers active HCMV infection from January 1996 to August 2004 in the Second Affiliated Hospital of Sun Yetsen University were divided into two groups. 23 neonates with congenital HCMV infection and 35 uninfected. They were followed up on physical and neurological development for 1-8years. Urine HCMV DNA was detected in 1st and 6th month. Results The rates of malformation, low DQ and hearing impairment were significantly higher in group of congenital HCMV infection than those in uninfected group(P<0.05). Conclusion Congenital HCMV infection can lead to developmental abnormality in fetuses, and has long-term effects on intelligence and hearing capability. Proper perinatal management, follow-up and early intervention must be carried out for those infected neonates.