补肾密骨液对切除卵巢大鼠实验性骨质疏松症骨质无机元素的影响

The Affection of Bushenmiguye to Inorganic Elements in Substance of Bone of Experimental Osteoporosis of Ovariolomy Rat

本文观察了补肾密骨液对切除卵巢大鼠诱导的实验性骨质疏松症骨质无机元素的影响，并与尼尔雌醇组、盐水组、模型组、正常组对照。用药三月后处死全部大鼠，测定胫骨骨质中的Ｃａ、Ｎａ、Ｋａ、Ｍｇ、Ｍｎ、Ｚｎ、Ｃｕ诸元素的含量。结果显示，中药组Ｃａ、Ｍｇ、Ｍｎ、Ｃｕ含量明显高于模型组及盐水组（Ｐ均＜０．０５），且与尼尔雌醇组比较无显著性差异。表明实验性骨质疏松症在病理发展和逆转过程中，Ｃａ、Ｍｇ、Ｍｎ、Ｃｕ这四种元素代谢十分活跃；提示在补肾密骨液作用下这四种元素含量增高，可能是该方治疗骨质疏松症的疗效机理之一。

This artical observed the affection of Bushenmiguye to inorganic elements in substance of bone of experimental osteoporosis of ovariolomy rat. and made comparing with saline group.model group. medel group and normal group.Using drugs three months later, executed all rat, assaied the content of Ca. Na.Ka.Mg. Mn.Zn.Cu in substance of tibia. The result showed: the content of Ca.Mg.Mn.Cu in Chinese drugs group obviously higher than model group and saline group (P all<0.05). This shows that experimental osteoporosis in pathology development and reversion process, the metobolism of four elements of Ca. Mg. Mu.Cu is very active; Point out that the content of these four elements increasing after using Bushenmiguye may be one of the curative mechanisms of this priscription treating osteoporosis.