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肿瘤特异靶向性药物载体的研究进展 被引量:5

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摘要 现代生物技术迅猛发展,针对肿瘤细胞的特异靶向性治疗面临着前所未有的机遇和挑战,同时,肿瘤治疗中的特异靶向药物载体也随着多学科综合性发展而不断出现,如抗体载体、配体载体、活性多肽载体、微粒复合载体等。通过对这些特异靶向药物载体的了解,有助于进一步研究和不断完善现有的肿瘤特异靶向治疗。本文综述了目前在临床和实验研究中几种常见的肿瘤特异靶向药物载体的研究进展。
出处 《国外医学(药学分册)》 CAS 2005年第3期151-155,共5页 Foreign Medical Sciences(Section of Pharmarcy)
基金 广东省自然科学基金资助项目(04006960)
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  • 1Klement G, Huang P, Mayer B, et al. Differences in therapeutic indexes of combination metronomic chemotherapy and an anti-VEGFR-2 antibody in multidrug-resistant hmnan breast cancer xenografts [ J ].Clin Gancer Res, 2002, 8(1) : 221 — 232.
  • 2Bemsen LG, Trail PA, Hellstro I, et al. Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model [ J ]. Neurosurgery, 2000, 46(3) : 704 — 709.
  • 3Guillemard V, Saragovi HU. Taxane-antibody conjugates afford potent cytotoxicity, enhanced solubility, and tumor target selectivity [ J ]. Cancer Res, 2001, 61(2) : 694 — 699.
  • 4Suzawa T, Nagamttra S, Saito H, et al. Enhanced tumor cell selectivity of adriamycin-monoclonal antibody conjugate via a poly ( ethylene glycol )-based cleavable linker[ J ]. J Control Release, 2002, 79( 1 - 3 ) : 229 — 242.
  • 5Kader A, Pater A. Loading anticancer drugs into HDL as well as LDL has little affect on properties of complexes and enhances cytotoxicity to human carcinoma cells[ J ]. J Control Release, 2002, 80( 1 - 3 ) : 29 — 44.
  • 6Herbst RS. Dose-comparative monotherapy trials of ZD1839 in previously treated non-small cell lung cancer patients[ J ]. Semin Oncol,2003, 30( 1 Suppl 1 ) : 30 — 38.
  • 7Xiong HQ, Abbmzzese JL. Epidermal growth factor receptor-targeted therapy for pancreatic cancer[ J ]. Semin Oncol, 2002, 29( 5 Suppl 14 ) : 31 — 37.
  • 8Yokoyama H, Goto S, Chert CL, et al. Major hepatic resection may suppress the growth of tumors remaining in the residual liver[ J ]. Br J Cancer, 2000, 83(8) : 1096 — 1101.
  • 9Li H, Qian ZM. Transferrin/transferrin receptor-mediated drug delivery[ J ]. Med Res Rev, 2002, 22(3) : 225 — 250.
  • 10Pattyn F, Speleman F, De Paepe A, et al. RTPrimer DB: the real-time PCR primer and probe database[ J ]. Nudeic Acids Res, 2003,31(1) : 122 — 123.

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