期刊文献+

抗乙型肝炎病毒药物的作用机制及靶点的研究进展 被引量:4

下载PDF
导出
摘要 目前,抗乙型肝炎病毒(HBV)面临的主要的挑战是当前药物疗效不很理想和耐药HBV株突变。现在的重要任务是发展一个治疗HBV感染的新策略,如发现的新靶点和针对多个靶点的联合治疗。本文对近年来抗HBV部分药物的作用机制和目前发现的抗HBV作用靶点进行综述。
作者 周侠 吕秋军
出处 《国外医学(药学分册)》 2005年第3期184-188,共5页 Foreign Medical Sciences(Section of Pharmarcy)
  • 相关文献

参考文献1

二级参考文献30

  • 1Maynard JE. Hepatitis B: global importance and need for control.Vaccine 1990: 8: (Suppl):S18-S20.
  • 2De Jongh FE, Jansen-HL, de Man RA, Hop WC, Schalm SW, van Blankenstein M. Survival and prognostic indicators of hepatitis B surface antigen-positive cirrhosis of the liver. Gastroenterology 1992, 103:1630-1635.
  • 3Davies SE, Portmann BC, O'Grady JG, Aldis PM, Chaggar K,Alexander GJ, Williams R. Hepatic histological findings after transplantation for chronic hepatitis B virus infection, including a unique pattern of fibrosing cholestatic hepatitis. Hepatology 1991;13:150-157.
  • 4Dusheiko GM. Treatment and prevention of chronic viral hevatitis. Pharmacol Ther 1995; 65:47-73.
  • 5Korenman J, Baker B, Waggoner J, Everhart JE, Di Bisceglie AM,Hoofnagle JH. Long term remission of chronic hepatitis B after interferon therapy. Ann Inter Med 1991; 114:629-634.
  • 6Hoofnagle JH, Lau D. Chronic viral hepatitis-benefits of current theravies. N Ene J Med 1996; 334:1470-1471.
  • 7Mazzella G, Saracco G, Festi D, Rosina F, Marchetto S, Jaboli F,Sostegni R, Pezzoli A, Azzaroli F, CanceUieri C, Montagnani M,Roda E, Rizzetto M. Long term results with interferon therapy in chronic type B hepatitis: a prospective randomized trial. Am J Gastroenterol 1999; 94:2246-2250.
  • 8Hadziyannis SJ. Hepatitis B e antigen negative chronic hepatitis B: from clinical recognition to pathogenesis and treatment. Viral Hepatitis Rev 1995; 1:7-15.
  • 9Cui L, Yoon S, Schinazi RF, Sommadossi JP. Cellular and molecular events leading to mitochondrial toxicity of 1-(2-de-oxy-2-fluoro-l-beta-D-arabinofuranosyl)-5-iodouracil in human livercells. J Clin Invest 1995; 95:555-563.
  • 10Nicoll A, Locarini S. Review: present and future directions in the treatment of chronic hepatitis B infection. J Gastroenterol Hepatol 1997; 12:843-854.

共引文献9

同被引文献41

  • 1冯云,熊文碧,王国兴,黄宁,吴琦,鲍朗,李绚,王伯瑶.人LAK细胞免疫效应分子HMGN2的鉴定[J].生物化学与生物物理进展,2005,32(6):568-575. 被引量:6
  • 2姚咏明,刘辉.对高迁移率族蛋白B1作用的新认识[J].中国危重病急救医学,2005,17(7):385-387. 被引量:60
  • 3Yun FEN Ning HUANG Qi WU Lang BAO Bo-yao WANG.(x-Helical domain is essential for antimicrobial activity of high mobility group nucleosomal binding domain 2 (HMGN2)[J].Acta Pharmacologica Sinica,2005,26(9):1087-1092. 被引量:8
  • 4马懿,冯云,李恒,黄宁,吴琦,王伯瑶.HMGN2的重组表达质粒的构建及其抗菌功能研究[J].四川生理科学杂志,2005,27(4):147-149. 被引量:7
  • 5骆抗先 编著.乙型肝炎[M].北京:人民卫生出版社,1997.329.
  • 6Grimm EA, Mazumder A, Zhang HZ,et al. Lymphoklne - activated killer cell phenomenon. Lysis of natural killer - resistant fresh solid tumor cells by interleukin 2 - activated autologous human peripheral blood lymphocytes[ J]. J Med Exp, 1982,155(6) :1823 - 1841.
  • 7Edwards KM, Davis JE, Browne KA, et al. Anti -viral strategies of cytotoxic T lymphocytes are manifested through a variety of granule - bound pathways of apoptosis induction [ J ]. Immunology Cell Biol, 1999,77 ( 1 ) : 76 -89.
  • 8Pena SV, Hanson DA, Carr BA, et al. Processing, subcellular localization, and function of 519 (granulysin), a hu- man late T cell activation molecule with homology to small, lytic, granule proteins [ J ]. J Immunol, 1997,158 (6) :2680 - 2688.
  • 9Agerberth B, Charo J, Werr J, et al. The human antimicrobial and chemotactic peptides LL - 37 and alpha - defensins are expressed by specific lymphocyte and monocyte populations [ J ]. Blood, 2000,96 ( 9 ) : 3086 - 3093.
  • 10Feng Y,Huang N,Wu Q, et al. HMGN2: a novel antimicrobial effector molecule of human mononuclear leukocytes [J]. J Leukoc Biol, 2005, 78(5) :1136-1141.

引证文献4

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部