川芎嗪对急性心肌梗死静脉溶栓后再灌注心律失常的影响

THE EFFECTS OF LIGUSTRAZINE (LT) IN THE TREATMENT OF REPERFUSION ARRYTHMIAS IN ACUTE MYOCARDIAL INFARCTION (AMI) AFTER INTRAVENOUS THROMBOLYTIC THERAPIES

目的观察川芎嗪对急性心肌梗死(AMI)静脉溶栓治疗(简称溶栓)后再灌注心律失常的影响。方法将339例符合溶栓标准的AMI病人随机分为治疗组和对照组,对照组给予常规治疗,治疗组加用川芎嗪120mg静脉滴注,每日1次。观察两组再灌注心律失常发生率的差异。结果治疗组171例,再通131例,再灌注心律失常的发生率56.1%(74/131)。对照组168例,再通120例,再灌注心律失常的发生率73.1%(87/120)。治疗组再灌注心律失常的发生率明显低于对照组(χ2=6.981,P<0.01)。结论川芎嗪对AMI溶栓后再灌注心律失常有明显的抑制作用。

Objective To observe the effects of ligustrazine (LT) in the treatment of reperfusion arrythmias in acute myocardial infarction(AMI) after intravenous thrombolytic therapies. Methods 339 patients with AMI were randomly divided into two groups. The patients of control group (168 cases) received routine treatment. The observation group (171 cases) was added LT 120mg every day by intravenous drip. The rates of reperfusion arrythmias were compared after treatment. Results In the observation group, 131 cases were reperfusion among 171cases. The rate of reperfusion arrythmias was 56.1% (74/131). In the control group, 120 cases were reperfusion among 168 cases. The rate of reperfusion arrythmias was 73.1% (87/120). The rate was remarkably lower in the observation group than the control group (χ~2 =6.981,P<0.01). Conclusions LT has markedly inhibitory effects in reperfusion arrythmias in AMI after intravenous thrombolytic therapies.