大黄对出血性休克大鼠肠粘膜通透性的影响

The Effect of Rhubarb on Intestinal Permeability of Rats with Hemorrhagic Shock

出血性休克后,肠源性内毒素血症是一个常见的病理过程.本实验旨在证明大黄是否对肠源性内毒素血症具有治疗作用.本文以Sprague-Dawley大鼠于颈动脉放血,血压5.32kPa维持1小时后予大黄(50mg/kg·次)分别于复苏后即刻、6、12小时经胃管注入.结果显示:大黄治疗组血浆内毒素水平明显低于休克组和安慰剂治疗组(P<0.01),小肠病理改变程度亦明显轻于休克组和安慰剂治疗组.可见大黄能明显降低出血性休克大鼠肠粘膜通透性,阻止肠道内内毒素吸收.

Enterogenous endotoxemia is a common pothphysiological process after hemorrhagic shock. The goal of the experiments was to determine weather Chinese traditional medicine rhubarb had a curative effect on enterogenous endotoxemia. Sprague-Dewley rats were bled through carotid artery, hypotension, 5. 32kPa, was maintained for one hour. The rhubarb (50mg/kg) was administrated to the rats via a stomach tube immediately after resuscitation and at 6.12 hours after resuscitation. The results showed that the rats treated with the rhubarb exhibited a very lower degree of endotoxemia than did the rats in shock group and in placebo group (p<0. 01);and the intestinal mucosal lesion of the rats in rhubarb group was also lighter. The rhubarb could obviously decrease intestinal permeability of the rats subjected to hemorrhagic shock and prevent endotoxin in the gut from absorbing.