急性上消化道出血的瘀血病理研究

Study on the Pathology of Blood Stmsls in Acute Upper Gastroin-testinal Hemorrhage

对59例急性上消化道出血病人血液流变学、甲襞微循环各项指标及各项指标加权积分值与得分率进行检测,并与30例健康人作比较.结果:(1)出血组血浆比粘度增高,红细胞电泳时间延长,P<0.01.全血比粘度及红细胞压积也增高,P<0.05;(2)出血组甲襞微循环突出表现为管襻形态异常,流速减慢及红细胞聚集,并伴有渗出与出血(P<0.01)等微循环异常改变.提示急性上消化道出血微循环和血液流变学的改变,与中医“瘀血”的病机相吻合.

59 Patients with acute upper gastrointestinal hemorrhage and 30 healthy subjects as control were measured by tests of Mood rhe-ology and nail-fold microcirculation. The results were: (1) plasma relative viscosity was higher and erythrocyte electrophoresis time was longer in hemorrhage group than those in control group (p< 0. 01). Blood relative viscosity and hematocrit in hemorrhage group were also higher than those in control group (p<0. 05). (2)The microcirculation of nail-fold in hemorrhage group showed abnormal shape of the vessel loop,slow Mood flow and erythrocyte aggreation, accompanied by oozing and hemorrhage around the vessel loop (p<0. 01). They suggest that the abnormal changes of microcirculation and blood rheology in patients with acute upper gastrointestinal hemorrhage are coincident with the pathologic essence of blood stasis of TCM.