肺表面活性物质治疗新生儿重症胎粪吸入综合征的疗效评价

Evaluation of surfactant therapy in newborn infants with meconium aspiration syndrome

目的评价外源性肺表面活性物质(PS)治疗重症胎粪吸入综合征(MAS)的疗效。方法将43例重症MAS病例随机分成两组,20例作治疗组,在上呼吸机及常规治疗同时应用PS治疗;23例患儿作对照组,予呼吸机及常规治疗,观察监测两组患儿的肺氧合功能、病程及预后。结果治疗后的不同时期,治疗组患儿的氧合指数低于对照组,差异有显著性(P<0.05);动脉/肺泡氧分压比值(a/APO2)高于对照组,差异有显著性(P<0.05);治疗组机械通气时间、用氧时间和住院时间均显著少于对照组(P<0.05)。结论PS治疗能有效地改善MAS患儿的肺氧合功能,可缩短应用机械通气及用氧的时间及病程。

Objective To study the efficacy of pulmonary surfactant(PS) in the newborn infants with severe meconium aspiration syndrome(MAS).Methods 43 infants with severe MAS were divided into 2 groups,20 cases were treated with PS,23 cases were treated with usual way.Results The mean oxygenation index(OI) and arterial/alveolar oxygen tension ratio(a/APO_2) of the PS group were improved significantly after treatment.The duration of mechanical ventilation,oxygen therapy,and hospital stay was significantly shorter in the PS group than those of control group.Conclusion PS therapy may result in a rapid improvement in oxygenation ,and reduce the duration of mechanical ventilation and hospitalization time of newborn infants with severe MAS.