罗格列酮减轻阿霉素肾病大鼠肾小球硬化的实验观察

Experimental observation of rosiglitazone on ameliorating adriamycin-induced glomerulosclerosis

目的观察罗格列酮干预治疗对单侧肾切除加重复阿霉素注射诱导的肾小球硬化大鼠肾脏的保护作用。方法建立单侧肾切除加重复阿霉素注射的肾小球硬化大鼠模型,分为罗格列酮治疗组和肾病组,设假手术组为对照组。检测各组大鼠第0、4、8、12周尿蛋白,并观察第12周肾组织病理改变,计算肾小球硬化指数。结果罗格列酮治疗组比肾病组尿蛋白排泄量明显减少(P<0.01),肾小球硬化程度明显减轻。结论罗格列酮对阿霉素肾病大鼠肾脏病变具有保护作用。

Objective To investigate the protecting effect of rosiglitazone on the kidney of the rats with uninephrectomized adriamycin-induced glomerulosclerosis. Methods Uninephrectomized adriamycin-induced glomeru-losclerosis rat models were established and randomized to three groups: treated rats, model rats untreated, and normal con-trols(sham operated group). At 0, 4, 8, 12 weeks, the 24-hour urine of the rats were collected from each group and the urinary protein were measured. At the 12th weekend, the renal histological changes were observed and glomerulosclerosis index were calculated. Results The urinary protein excretion of treated rats group was significantly lower than that of model rats group(P<0.01), and the degree of glomerulosclerosis in treated rats group reduced markedly. Conclusion Rosiglitazone has some protective effects on rats with adriamycin-induced glomerulosclerosis.