摘要
早产的病因中10%～30%是感染因素。细胞因子参与炎症反应和早产过程。实验证明在细胞因子的作用下,妊娠组织合成花生四烯酸增加,合成前列腺素E2,激活子宫肌层,引起子宫收缩,早产。细胞因子基因的多态性亦与早产相关:胎儿携带IL鄄1B+3953鄄2和IL鄄1RN鄄2、母体或胎儿的TNFA鄄308(TNFA鄄2)的多态性、母体TNF鄄863AA基因型、母体或胎儿携带IL鄄4鄄T都会增加早产的风险;而携带IL鄄10鄄A基因型与早产无明显相关性。对感染致早产的细胞因子和相关基因的进展做简要综述。
出处
《国外医学（妇产科学分册）》
2005年第3期136-139,共4页
Foreign Medical Sciences(Obstet Gynecol Fascicle)
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