氟康唑的合成

Synthesis of fluconazole

目的改进氟康唑(fluconzole1)的合成工艺。方法用间二氟苯为起始原料,经四步反应制得氟康唑,合成过程中分别采用聚乙二醇等作相转移催化剂。结果所得氟康唑产物符合《中国药典》2000年版标准。结论产品纯度达98.5%以上,工艺可靠,质量稳定。

OBJECTIVE To improve the synthetic technology of fluconazole.METHODS Fluconazole was produced by 4 steps reactions with m-difluorobenzenes as starting material, and PEG as phase-transfer catalyst in synthesization. RESULTS The product could remove impurity of identical structure after recrystallzation,with a yield above 50%.CONCLUSION The purity of product is above 98.5%,The quality is stable and the process was reliable.