头颈部肿瘤组织中纤溶酶原激活物的测定

Determination of Plasminogen Activator of the Head and Neck Tumor Tissue

采用纤维蛋白板测定头颈肿瘤组织中纤溶酶原激活物（ＰＡ），结果表明：①头颈恶性肿瘤原发灶、颈淋巴结转移癌ＰＡ活性增高，比活性均值高于相应癌灶邻近正常组织和头颈良性肿瘤组织（Ｐ＜０．０１）；②在原发灶中ＰＡ比活性均值随肿瘤分期的进展而递增。提示ＰＡ可能是参与头颈恶性肿瘤生长、浸润及转移的机制之一，ＰＡ使头颈癌细胞激活纤溶系统降解癌周组织而浸润、转移。

Fibrin plate was used to determine plasminogen activator(PA)of the head and necktumor tissue. The results revealed:1. The specific activity of PA of primary malignant tumor and neck lymphatic metastatic nodes were higher than that of normal tissue near cancer and benign tumor tissue;2.The specific activity of PA was enhanced as advance of tumors in clinical stage. This study implicated that PA released from cancer cells can catalyze and convert plasminogen to plasmin,which results in tissue degradetion, invation and metastasis of tumor.