影响IgA肾病高尿酸血症的因素

The Influence Factors on the Incidence of Hyperuricemia in IgA Nephropathy

目的:探讨IgA肾病高尿酸血症的影响因素及其与肾内动脉病变的关系。方法:对6 4 8例IgA肾病患者进行回顾性研究,应用多元回归的统计学方法分析高尿酸血症发生的影响因素。结果:IgA肾病患者中高尿酸血症的发生率为2 9.6 %。与高尿酸血症独立相关的因素为:血清肌酐升高、高甘油三酯血症、高血压、肥胖及肾内动脉病变。血尿酸的水平与IgA肾病肾内动脉病变的程度密切相关。结论:有效地控制血压和体重、降低血脂及血尿酸水平,可望减轻肾内动脉病变,延缓IgA肾病的进展。

Objective:To analyze the independent influence factors on hyperuricemia and its association with intrarenal arterial lesions in IgA nephropathy.Methods:A retrospective study was carried out in 648 cases with IgA nephropathy diagnosed by renal biopsy. The multivariate analysis was performed to identify the association between hyperuricemia and clinico-pathological factors.Results:The incidence of hyperuricemia in IgA nephropathy was 29.6%.The high level of serum creatinine(>110 μmol/L),hypertriglyceride, hypertension, obesity and intrarenal arterial lesion were independently correlated to hyperuricemia.The level of serum uric acid was significantly associated with the incidence of intrarenal arterial lesion in IgA nephropathy.Conclusion:To control hypertension and body weight, reduce blood lipid and uric acid level effectively would be helpful for alleviating the intrarenal lesions and delaying the progression of IgA nephropathy.