胃癌组织阿片肽含量变化

Change of Endogenous Opiate Peptide Contents in Gastric Cancer Tissue

用放射免疫分析检测胃角部癌组织阿片肽含量,结果表明亮—脑啡肽含量在癌中心和边缘处明显升高,以前者为甚,癌周3cm处则与对照相近;强啡肽A_(1—13)和β—内啡肽含量以癌中心处降低最为显著,边缘处次之,癌周3cm处接近正常;但是胃癌组血浆阿片肽含量与对照组无显著差异.揭示胃癌发生发展可能与阿片肽含量变化有关.

Radioimmunoassay was used to measure the endogenous opiate peptide contents in gastric cancer tis-sue. It was shown that the L-enkephalin content was markedly elevated in gastric cancer tissue, especially at the core of the tumor, while a normal level content was shown in the tissue 3cm away from the tumor edge. The dynorphin Al-13 and be-ta-endorphin contents decreased in gastric cancer tissue being lowest in the center of the tumor as compared with the tumor periphery and tissues 3cm away from the the cancer. But the plasma endogenous opiate peptide levels in gastric cancer patients were as high as those in control individuals. It is suggested that the endogenous opiate pepfides might play a part in the development of gastric cancer.