胃癌宿主脾脏免疫功能的实验与临床研究

Experimental and Clinical Study of Splenic Immunopotency in GastricCancer Patients

对15例胃癌大鼠及40例胃癌患者外周血与脾脏细胞的NK、LAK活性、T细胞亚群等进行了对比研究.结果发现进展期胃癌能削弱宿主的整体免疫功能,其中脾脏所受影响尤为明显,具体表现为脾脏细胞NK活性及其对rlL-2刺激反应性显著抑制,CD_4^+/CD_8^+细胞比值下降.研究结果为临床上合理地开展胃癌扩大根治术提供了免疫学依据.\

In order to study the immunopotency of the spleen in patients with advanced gastric can-cer(AGC),NK cell.LAK cell activities and T-lymphocyte subsets of spleen cells(SC)and peripheral bloodlymphocytes (PEL) from 15 gastric cancer-bearing rats and 40 cases of AGC patients were observed. The results showed that (1)as compared with normal controls,NK and LAK activities of SC and PEL were significantly lower in cancer hosts,especially for SC; (2)more significant reduction of CD^4+/CD8+ cell ratio was found in SC when compared with PBL in AGC patients principally due to marked decline of CD4+ cells in SC. In conclusion, with the progress of the gastric cancer the immune function of the patients weakens and immunosup-pression in the spleen takes place gradually.