血清E-选择素和血清C-反应蛋白在急性冠状动脉综合征患者中的变化及意义

Changes of serum soluble E-selectin and CRP in patients with acute coronary syndrome

目的:观察血清E选择素、血清C反应蛋白(CRP)水平在急性冠状动脉综合征(ACS)患者中的变化,并探讨其与斑块稳定性的关系。方法:30例ACS患者(ACS组)、24例稳定型心绞痛(SAP)患者(SAP组)及30例冠状动脉造影阴性者(对照组)作为入选对象,均以酶联免疫吸附法(ELISA)检测其E选择素,免疫速率散射测浊法测定其CRP水平。结果:ACS组血清E选择素、CRP水平显著高于SAP组(P<0.01)和对照组(P<0.01)。结论:血清E选择素、CRP可能与ACS发病有关,并反映斑块的不稳定性。

Objective:To observe changes of serum levels of soluble E-selectin and C-reactive protein(CRP) in patients with acute coronary syndrome. Method: Thirty patients with acute coronary syndrome(ACS), 24 patients with stable angina pectoris(SAP), 30 controls with negative coronary angiography.We measured the serum level of soluble E-selectin by means of enzyme linked immunosorbent assay (ELISA) and CRP by ultrasensitive immunoassay ( rate nephelometry with the Beckman Immunochemistry Systems). Result:The serum levels of soluble E-selectin and CRP in the ACS group were significantly higher than those in the SAP group(P< 0.01)and controls(P< 0.01). Conclusion:E-selectin and CRP may be involved in the pathogenesis of ACS and relate to the unstability of plaques.