经动脉化疗性栓塞术治疗晚期肾癌的经验

Transartery-chemicoembolization for the Treatment of Renal Tumor

用聚乳酸(polylactic Acid)与丝裂霉素C(Mitomycin C)研制成可控释性微球-PLA·MMC,实验研究证明其抑瘤和缓释作用。1989年8月应用于临床,经动脉插管注入PLA·MMC治疗肾癌6例,其中3例巨大肾癌术中出血少,易剥离顺利切除,余3例晚期肾癌行单纯性化疗栓塞术,近期疗效满意。

Mitomycin C (MMC) was blended with polylactic acid (PLA) in the form of microsphefes which was considered to release drugs under control. Experimental studies confirmed their effects of tumor inhibition and sustaining release of drug. The PLA, MMC microspheres were injected through catheter into the renal arteries in 6 cases of renal cancer, 3 of which with bulky tumors were resected successfully with minimal bleeding and easiness in manipulation during the operation. The remaining 3 cases received a simple chemicoembolization therapy with satisfactory effect. There was no serious complication encountered.