原发性肝癌患者可溶性IL—2受体水平、IL—2和NK活性的变化及意义

Observation on SIL-2R Levels and Activities of IL-2 and NK Cells in Patients with Primary Hepatocellular Carcinoma

采用双抗体夹心ELlSA法检测43例原发性肝细胞癌(PHC)病人血清可溶性白细胞介素2受体(sIL-2R)水平,及其外周血单个核细胞(PBMC_s)的白细胞介素2(IL—2)活性和自然杀伤(NK)细胞活性.另将51例慢性乙型活动性肝炎和肝硬化病人做为对照.结果,上述病人血清sIL—2R水平明显升高,IL—2和 NK活性低于正常人,其中PHC的IL—2和NK活性的降低又为显著(P<0.001< O.001).表明PHC病人的细胞免疫功能受损程度最重.检测sIL_2R水平和IL—2活性,可望做为对PHC患者病情分析及判断预后的指标.

Serum soluble IL - 2 receptor (SIL - 2R)levels and activities of IL - 2 and NK cells in 43 patients with primary hepatocellular cancer (PHC)and in 51 cases of chronic active hepatitis (CAH) B and liver cirrhosis (LC) as control were observed. The results showed that SIL-2R levels in PHC patients were much higher than that in healthy subjects. The activities of IL -2 and NK in cases with PHC were significantly lower than those in CAH and LC. It is suggested that the levels of SIL - 2R and IL-2 may be a new parameter for the estimation of the seriousness of the disease as well as judgement of prognosis in PHC patients.