高剂置率近距离放射治疗鼻咽癌的近期临床观察

Preliminary Study on HDR Brachytherapy for Nasopharyngeal Carcinoma

本文报告４８例采用外照射加腔内反装治疗鼻咽癌患者。其中计划性内、外照射２９例，外照射未控补加腔内治疗９例，外照射放疗后鼻咽局部复发１０例。腔内治疗使用＾１９２Ｉｒ放射源，外照射总量５０００－８５００ｃＣｙ。腔内治疗每次参考点剂量５００－１０００ｃＧｙ，总量１５００－２５００ｃＧｙ。总鼻咽局部控制率９１．７％。高于单纯外照射。为顽固性鼻咽癌的治疗提供了新方法。

Forty-eight patients with NPC proved pathologically were treated by using external irradiation combined with brachytherapy. Among them,combined intracavitary irradiation was planned initially in 29 cases,as a supplementary treatment after external radiation in 9 incidences for uncontrolled lesion and for tumor recurrence in 10 cases. The source of radiation used in brachytherapy was 192Ir, with the reference point dose ranging from 5-10Gy each time and the total dose of 15-25Gy. The overall dosage for external irradiation was 50-85Gy.The results showed that the local control rate in this series was 91. 7%,which was better than external irradiation alone. The authors believe that combined HDR (High dose rate) brachytherapy is an effective method for treatment of nasopharyn-geal carcinoma.