钇—90玻璃微球制剂局部注入对裸鼠移植性人肝癌的疗效观察

Experimental Treatment of Liver Cancer with Yttrium-90 Glass Microspheres

目前,微球制剂为肿瘤治疗、特别是中晚期癌症的治疗,提供了新途径.本文报告了应用90y玻璃微球制剂治疗BALB/C裸小鼠移植性人肝癌的效果.结果表明,90y在适宜吸收剂量,治疗后1月～2个月,对移植性肝癌显示3种疗效,即癌作消失,癌体缩小及癌作溃烂、脱落.若剂量过大,引起“β损伤”,形成难以愈合的溃疡面,组织学显示相应改变.因此治疗时,应选择合适的注入量(活度)和吸收剂量,同时90y制剂要纯,并注意防护、防止污染.

Treatment of liver cancer has achieved remarkable effect with various Y-90 glass microspheres in recent years and has provided a noticeable prolonged survival for patients. In this study,Y-90 glass microsphere have been given by means of external regional infusion therapy to BALB/C nude mice bearing liver cancer transplanted from man. The results of the experiment showed that the dose absorbed by the malignant tissues can reach from 34lGy to 273lGy,and three types of changes of the liver cancer may occur during the first or second month after treatment e. g. disappearance of the cancer mass, reduced size of the tumor and sloughing off of tumor . The first two of the changes can be caused by smaller or moderate dose, the third one caused by large dose (e. g. 2731 Gy). Histological changes varied with dose absorbed by the tissues from local necrosis to wide-spread necrosis. The results 'suggested that the optimal therapeutic dose in treating patients is probably dependent upon tumor size and that the microspheres must be disinfected and prevented from any contamination.