206例垂体腺瘤的免疫组化、电镜及内分泌特征的研究

Immunocytochemical and Ultrastructural Study of 206 Pituitary Adenomas with Endocrinological Analysis

本文采用免疫组化及电镜观测分析了206例垂体腺瘤,根据激素分泌及超微结构特征将肿瘤分为11类.其中泌乳素腺瘤最常见(35.92%);其次是生长激素腺瘤(19.42%);零细胞腺瘤(16.50%)等.本文借助流式细胞术DNA分析研究了38例术后复发的垂体腺瘤后认为:嗜酸性干细胞腺瘤和伴Nelson综合征的促肾上腺皮质激素腺瘤有术后复发的倾向;此外,侵袭性生长的腺瘤和流式细胞术测定时DNA含量较高的DNA异倍体腺瘤的恶性度相对较高,术后易于复发.

Retrospective immunocytochemical and ultrastructural studies were performed on 206 cases of pituitary adenomas. Of 11 types of tumours the commonly seen were PRL-secreting adenomas (35. 92%), GH-secreting adenomas (19. 42%) and null cell adenomas (16. 50%). In 38 post-operative recurrent tumours studied with the flow cytometric DNA analysis, it was noted that the acidophilic stem cell adenoma and the ACTH-secreting adenoma with the Nelson's syndrome tended to recur. The invasive growth and the DNA aneuploidy usually indicated the malignant behavior of tumours which were predisposed to recur after operation.