人舌及涎腺中狂犬病毒抗原分布的观察

Distribution of rabies antigen in human tongue and salivary gland

用免疫酶组化染色ＡＢＣ法，研究了３例狂犬病人舌及３例涎腺中狂犬病毒抗原（ＲＶＡｇ）的分布。在２例４／５舌切片中见其浆液腺细胞、末梢神经、少数横纹肌纤维及复盖上皮包括味细胞中含大量ＲＶＡｇ颗粒，１例舌切片中无浆液腺，为阴性反应。在３例４／９大涎腺切片中只在腺叶内或末梢神经有少量弱反应的ＲＶＡｇ。与以往报告的病犬、狐、臭鼠大涎腺中含大量ＲＶＡｇ不同。人大涎腺中ＲＶＡｇ含量远比舌中为少。人舌浆液腺区可能是ＲＶＡｇ多见部位，可能是一传染源。

he distribution of rabies virus antigen (RVAg) in human tongue and salivary glands from three cases was studied with ABC immunohistochemical method. Of the 5 tissue blocks from 2 tongues,large amounts of RVAg were found in 4 tissue blocks, located in the serous glands,terminal nerves, some striated muscle fibers and some covering epithelium including taste cells of circumvallate papillae。 Only small amounts of RVAg were present in 4 of the 9 salivary gland blocks, either within the acini or in nerves. These results differ from that reported previously in dog, fox and skunk salivary glands, which contained abundant RVAg. The amount of RVAg in human tongue is apparently greater than that in the salivarylglands.It is probable that the serous glands of the human tongue are sites of predilection for RVAg and may serve as a source ofinfection。