大肠粘液腺癌浸润机理的研究

A study on tke mechanism of invasion of colorectal mucinous adenocarcinoma

对６４例大肠癌标本的统计结果表明，粘液腺癌易于浸润肠壁和伴淋巴结转移，并发现其芳香硫酸酯酶和溶菌酶（ＬＺＭ）活性高于乳头状癌和管状腺癌。电镜观察粘液腺癌间质钉红颗粒明显减少。以上结果提示粘液腺癌分泌了芳香硫酸酯酶和ＬＺＭ，它们能够水解硫酸肝素上的硫酸基团和蛋白多糖分子结构中的Ｎ一乙酰氨基葡萄糖的连接，使这类蛋白多糖的硫酸化程度降低和降解，导致蛋白多糖的屏障结构破坏，使粘液腺癌易于浸润和转移。

tatistics from a 64 case study showed that mucinous adenocarcinoma was apt to invade the intestinal wall and to metastsize to lymph nodes(P<0. 05 ).The activity of arylsulfatase and lysozyme of mucinous adencarcinoma was stronger than that of the papillary and tubular adenocarcinoma(P<0. 05 ).In RR staining for electron microscopic observation,a significant decrease of proteoglycan granulaes was found in the surrounding matrix of mucinous adenocarcinoma,which correlated with the amount of arvlsulfatase and lvsozvme secreted bv mucinous adenocarcinoma. These enzymes reduced the degree of sulfation in heparan sulfate and degraded proteoglycans. The proteoglycan structural barrier having been destroyed, facilitates mucinous adenocarcinoma to infiltrate and metastasize.