甲型肝炎患者淋巴细胞mIL－2R的表达及血清sIL－2R释放的动态变化

DYNAMIC CHANGES AND CORRELATION OF SERUM SOLUBLE INTERLEUKIN 2 RECEPTOR WITH MEMBRANE INTERLEUKIN 2 RECEPTOR OF LYMPHOCYTES IN HEPATITIS A PATIENTS

对５２例甲型肝炎（甲肝）患者血ＴＩＬ－２Ｒ释放水平进行了动态观察，并对患者ＰＢＭＣｍＩＬ－２Ｒ的表达进行了同步监测。发现在甲肝急性期，ｍＩＬ－２Ｒ的表达（２０．５５±１０．５２％）及ｓＩＬ－２Ｒ的释放（６６４．１３±４８８．８４ｕ／ＭＬ）均较正常对照组（７．５５±４．２８％，Ｐ＜０．００１；１８８．９０±１２２．９１ｕ／ｍＬ，Ｐ＜０．００１）显著增强，恢复期（９．３２±６．２０％；２０６．７８±１７６．０７ｕ／ＭＬ）两者均基本降至正常水平。相关分析发现ｍＩＬ－２Ｒ的表达与ｓＩＬ－２Ｒ的释放存在显著的正相关，两者与ＡＬＴ之间亦显著相关。提示ｍＩＬ－２Ｒ的表达及ｓＩＬ－２Ｒ的释放可能与甲肝患者的肝损伤有关。

e observed the dynamic changes of soluble interleukin 2 receptor(SIL-2R)fromserum of 52 hepatitios A patients and membrane interleukin 2 receptor(mIL-2R)of thepatients'peripheral blood mononuclear eells(PMBC).Results show; In acute phase,theexpression of mIL-2R(20.55 ±10.52%)and the release of sIL-2R(664.13 ±488.84u/ml)increase significantly than the control(7.55 ± 4.28%, P<0. 001;188.90 ± 122.91u/ml,P<0.0l); In convalescence(9.32 ± 6.20% : 206.78 ± 176.07u/ml),both of them return al-most to normal. The correlational analyses suggested that slL-2R and mIL-2R showedremarkable positive correlation;both of them also have significant positive correlationswith ALT. The results suggestesd that sIL-2R and mIL-2R might have something to dowith the destruction of hepatocytes in patients with hepatitis A.