浙江省耐甲氧西林金黄色葡萄球菌流行状况及耐药性

STUDY ON THE EPIDEMIOLOGY AND DRUG RESISTANCE OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS(MRSA)IN ZHEJIANG PROVINCE

对我省各地区１９９１年６月至１９９２年１２月间收集的１７０株临床分离的金黄色葡萄球菌的研究表明：在我省同样存在耐甲氧西林金黄色葡萄球菌（ＭＲＳＡ）的流行，在１７０株菌株中共检出了ＭＲＳＡ４４株，占同期金黄色葡萄球菌的２５．９％，且在大多数地区都检测到了ＭＲＳＡ菌株；对其耐药性进行研究发现，ＭＲＳＡ菌株对大多数抗生素的耐药率都比较高，对有的抗生素的耐药率在９０％以上，耐药程度明显高于甲氧西林敏感的金黄色葡萄球菌（ＭＳＳＡ），但对万古霉素全部敏感。

e studied 170 strains of staphylococcus aureus isolated from various kinds of clinical specimens collected from different districts of Zhejiang province‘from june 1991 to december 1992. The result showed that methicillin-resistant staphylococcus aureus(MRSA)is also epidemic in our province.as other districts reported.We isolated out 44 strains of MRSA out of the 170 strains isolated,the isolation rate was 25.9%. MRSA strain was isolated from most of the areas in our province. Drug susceptibility test of the 44 MRSA strains revealed that the antibiotic resistance rate were more than 50% to fluoroquinolones,aminoglycosides and most of the cephalosporins-To some of the antibiotics the drug resistant rate was more than 90%, it was obviously higher than methicillin-sensitive staphylococcus aureus(MSSA).However,all the staphylococcus aureus strains(including MRSA and MSSA)were sensitive to vancomycin.