摘要
用原子吸收光谱法及比色法分别测定了大鼠脑挫伤后伤灶组织总钙(Cat)、组织总磷(Pt)含量的动态变化,用Ca2+通道阻滞剂异搏停进行了治疗。结果表明:伤后2小时内即出现挫伤区的Ca2+内流以致Cat增加,8小时达高峰并至少维持7天;Ca2+内流后可诱发组织细胞的继发性破坏以致Pt丢失。异搏停可以部分阻止Cat增高及Pt降低,故对受损组织有一定保护作用。
The contents of Calcium(Ca) and phosphorus (P) in lesioned sites of rats with cerebral contusion were assessed by atomic absorption spectroscopy (AAS) and chromometry respectively and Ca 2+ channel blocker (CCB), Verapamil was used for study of the treatment. The results indicated (1) primary trauma may cause Ca 2+ influx into the injured regions and lead to Ca 2+ increase at 2h and the maxincal increase at 8h which lasted at least for 7 days; (2) Ca 2+ influx may instigate secondary injury to brain tissue, which results in the lose of P; (3) Verapanil might partially alleviate the increase of Ca 2+ and the decrease of P. It is considered that verapamil is protective to the injured brain cells in certain extent.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
1994年第1期22-23,共2页
Chinese Journal of Trauma
关键词
脑外伤
磷
钙
异搏停
Brain injury Calcium Phosphorus Ca 2+ channel blocker