脑外伤后脑组织钙、磷含量变化及异搏停的保护作用

Changes of Contents of Tissue Ca. P in Brain Injury and Effects of Verapamil

用原子吸收光谱法及比色法分别测定了大鼠脑挫伤后伤灶组织总钙（Ｃａｔ）、组织总磷（Ｐｔ）含量的动态变化，用Ｃａ２＋通道阻滞剂异搏停进行了治疗。结果表明：伤后２小时内即出现挫伤区的Ｃａ２＋内流以致Ｃａｔ增加，８小时达高峰并至少维持７天；Ｃａ２＋内流后可诱发组织细胞的继发性破坏以致Ｐｔ丢失。异搏停可以部分阻止Ｃａｔ增高及Ｐｔ降低，故对受损组织有一定保护作用。

The contents of Calcium(Ca) and phosphorus (P) in lesioned sites of rats with cerebral contusion were assessed by atomic absorption spectroscopy (AAS) and chromometry respectively and Ca 2+ channel blocker (CCB), Verapamil was used for study of the treatment. The results indicated (1) primary trauma may cause Ca 2+ influx into the injured regions and lead to Ca 2+ increase at 2h and the maxincal increase at 8h which lasted at least for 7 days; (2) Ca 2+ influx may instigate secondary injury to brain tissue, which results in the lose of P; (3) Verapanil might partially alleviate the increase of Ca 2+ and the decrease of P. It is considered that verapamil is protective to the injured brain cells in certain extent.