老年手术患者术前血小板聚集的变化

Platelet Aggregation in Older Surgical Patients

研究一组老年手术患者在术前血小板聚集功能的变化，并和成年组相比较。老年组２０例（恶性肿瘤１１例，非肿瘤９例），成年组２０例（均非肿瘤患者）为对照组。用双道血小板聚集仪测定血小板聚集强度（率）。结果表明老年组血小板聚集率比成年组明显增高，差异有显著性。提示老年人血小板聚集率增高为一潜在危险，在手术创伤、麻醉和急救复苏中应高度警惕，防止发生栓塞病。

The blood of older patients is of hypercoagulability under the influence of a variety of factors. The purpose of this study was to see the preoperative change of platelet aggregation in a group of older surgical patients (over 60 years old), and to compare with adult group. None of inhibitors of platelet aggregation have been used in all patients, and without liver or kidney diseases, acute infection etc in the patients. Senile group 20 cases, age 60 to 80 years, included malignant tumour in 11 cases and non tumour in 9 cases. Adult group 20 cases, age 18 to 30 years, serve as control group. 2.7ml venous blood were drawn with silicified syrings, anti coagulated with 3.8% citric acid. PRP and PPP were prepared. Platelet aggregation was measured by double channel platelet aggregator. It is showed that platelet aggregation of old group was 59.34±8.16%, adult group was 52.84±8.89%, the difference between the two groups was significant ( P <0.01). The platelet aggegation of malignant tumour patients was 59.00±8.09% and non tumour patients was 59.74±7.60% among the senile group, the difference was no significant ( P <0.05). It is showed that platelet aggregation of old patient were apparently greater than adult group. It is a potential danger that platelet aggregation of old patients increased, which must be prevent during the period of operation, anesthesia, and resuscitation.