高压氧治疗对骨折后碱性磷酸酶活性的影响

Effect of Hyperbaric Oxygen on Alkaline Phosphatase in Rabbit Callus Resulting from Fracture

通过４４只家兔桡骨骨折后在高压氧（ＨＢＯ）治疗下，对２、３、４、６、８、１０周各期骨痂中碱性磷酸酶（ＡＫＰ）的活性测定并结合电镜观察，发现骨折后３～４周时ＨＢＯ组ＡＫＰ活性高于对照组。骨折后４周内两组骨痂中ＡＫＰ活性均高于正常尺骨干骺端骨和皮质骨ＡＫＰ活性，１０周时与正常尺骨皮质骨中ＡＫＰ活性相似。骨折后６周内成骨细胞、成纤维细胞的细胞器发达，代谢功能活跃；６周以后细胞呈退变状态。提示高压氧对骨折的治疗作用在于促进ＡＫＰ的代谢过程，是基于骨折后６周内成骨功能细胞功能活跃的基础上。６周以后，成骨功能细胞趋于衰减，此时ＨＢＯ失去作用基础，治疗意义不大。

he radialis fractures of the rabbits were treated by the hyperbaric oxygen (HBO)to observe the changes of the Alklil1e phos-phatase (AKP)in formed callus at2,3,4,6,8,10 week post-fracture. As a result, the AKP activity in the HBO group was muchhigher than in controls(no HBO treated),which therefore suggests that the role of the HBO on the fracture may be duo to a pro-motion to the AKP metabolism in the callus:furthermore,the effect works within 6 weeks,later,HBO treatment doesn’t work.(Original article on page 169)