脑外伤后心房肽含量变化及其对颅内压的影响

The Change of Atrial Natriuretic Peptide Concentrations in Plasma and CSF and It’s Effects on Intracranial Pressure after Acute Head Trauma

对２０例急性重型颅脑损伤血浆及脑脊液（ＣＳＦ）中心房肽（ＡＮＰ）含量动态检测结果表明，脑外伤后血浆及ＣＳＦ中ＡＮＰ含量显著减少。比较不同病理类型脑外伤后ＡＮＰ含量，以具有脑实质性损伤的硬膜下血肿、脑挫裂伤或脑内血肿ＣＳＦ中ＡＮＰ减少较硬膜外血肿更为显著。另对９例颅内压（ＩＣＰ）监护患者静脉应用ＡＮＰ后，发现ＡＮＰ具有缓解脑外伤后颅内压增高的作用。

he concentrations of atrial natriuretic peptide(ANP)in plasma and CSF were determined in 20 head trauma patients by usingRIA in this study.The results showed that the ANP concentrations in plasma and CSF were decreased significantly,and were low-er in the patients of subdural hematoma complicated with brain contusion or intracerebral hematoma than that in the patients withepidural hematoma. When 200ug ANP was adminitered intravenously to 9 head trauma patients.the intracranial pressure(ICP)monitoring showed that increased ICP could be decreased.