围产儿出生缺陷综合措施防治干预效果分析

Encircles produces the birth flaw synthesis measure preventing and controlling intervention effect analysis

目的:了解深圳市罗湖区3年围产儿出生缺陷发生情况及其相关因素的影响,分析实施干预措施对降低围产儿出生缺陷发生的有效性.方法:对深圳市罗湖区2002～2004年围产儿出生缺陷监测资料进行相关因素的回顾性调查分析.结果:3年共监测围产儿22 912例,发现出生缺陷308例,出生缺陷发生率13.44‰.前5位缺陷种类依次为:多指(趾)、唇腭裂、地中海贫血、马蹄内翻足、先天性心脏病,发病率分别为:1.70‰、1.48‰、L 13‰、0.87‰、0.79‰.通过实施干预项目,常住+暂住人口出生缺陷发生率显著下降(x2=3.99,P＜0.05);产前确诊率明显提高;孕期筛查严重缺陷儿全部终止妊娠.结论:必须大力加强优生遗传咨询指导及孕28周前的产前诊断工作,采取有利措施加强流动人口孕产妇保健管理,降低流动人口出生缺陷发生率.

Objective:To understand the situation and its influence from related factors of perinatal defect in birth of the latest 3 years in Shenzhen Luohu district and to analyze the validity by implementing interventing measures to reduce the occurrence of perinatal defect in birth.Methods:To review monitor materials regarding related factors of perinatal defect in birth in Shenzhen Luohu from year 2002~2004.Results:There are 22 912 perinatal cases, and 308 cases of defect in birth. The probability of having defect in birth is 13.44‰. The main 5 types of the defect are polydactyly, cleft palate, the Mediterranean Sea anemia, the horse's hoof club foot, the congenital heart disease and the disease incidence rate respectively are 1.70‰、1.48‰、1.13‰、0.87‰、0.79‰. Through implementing the intervening project, the probability of having defect in birth of permanent and temporary residents drops remarkably ( χ 2 =3.99, P < 0.05); The confirmed rate pre-natal diagnosis increases significantly. The serious defect checked randomly in gestation period all terminate the pregnancy completely.Conclusion:Must strengthen the eugenics heredity consultation instruction and the 28-week diagnosis before giving birth. Adopt the facilitated measures to strengthen puerperal and gravida's health care management of floating population to decrease the probability of having defect in birth of floating population.