年长儿童的气道反应性测定

MEASUREMENT OF BRONCHIAL RESPONS-IVENESS IN ELDER CHILOREN

采用简易组织胺支气管激发试验对１１～１４岁儿童１５０７例作气道高反应性（ＢＨＲ）研究。结果：儿童的呼气峰速与身高显著相关；男女各年龄组激发试验时通气功能的改变率无显著差异；本组儿童ＢＨＲ发生率为４．０％；现患哮喘儿童的ＢＨＲ发生率及严重程度显著高于曾患哮喘者，有哮喘史者亦显著高于正常儿童。激发试验中未见严重不良反应。简易激发试验敏感性高，安全，操作方便，适用于年长儿童气道反应性的临床及流行病学调查。

AbstractHistamine bronchial provocation test was performed todetect the bronchial responsiveness in 1507 students aged11-14 years. It was shown that the peak flow value wassignificantly related to the height of the children. No signifi-cant differences were found among different age groups in thechanges of ventilation function after bronchial provocationtest. The prevalence of bronchial hyperresponsiveness (BHR)was 4.0%. The prevalence and the severity of BHR inchildren with current asthma were sighificantly higher thanthose who had asthma previously and the prevalence and theseverity of BHR in children with a history of wheezing werealso significantly higher than those without such a history.No severe adverse effects were found during and after thebronchial provocation test. Histamine bronchial provocationtest is suitable for evaluation of the bronchial reactivity of el-der children in clinical and epidemiological research becauseof its sensitivity, safety and ease in operation.