期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

猪下丘脑开胃素A的分布定位 被引量：7

Localization of orexin A in the pig hypothalamus
下载PDF
导出
摘要 用免疫组织化学方法研究了5头苏钟猪下丘脑内开胃素(orexin)A的分布。结果表明,在猪下丘脑内,开胃素A免疫阳性神经元分布于下丘脑的视前内侧区、室周核、室旁核、视上核、背内侧核、穹隆周核、乳头体核、前区、外侧区和后区等部位,以下丘脑外侧区、乳头体核和视上核出现的免疫阳性神经元最多,以室周核的最少。这一结果与在其他动物上获得的基本相似。 The localizations of orexin A in the hypothalamus of five pigs were studied by immunohistochemistry method.The results showed that orexin-like immunoreactive(orexin-IR)neurons were observed in the medial preoptic nucleus,periventricular nucleus,paraventricular nucleus,supraoptic nucleus,dorsomedial nucleus,perifornical nucleus,mammillary nucleus,anterior area,lateral area and posterior area of the hypothalamus,with majority in the lateral area,supraoptic nucleus and mammillary nucleus and with minority in the periventricular nucleus.The results obtained were similar to those obtained in other animals.
作者 李庆梅 雷治海 陈敏 邓碧华 苏娟
机构地区 南京农业大学动物医学院
出处 《南京农业大学学报》 CAS CSCD 北大核心 2005年第2期99-102,共4页 Journal of Nanjing Agricultural University
基金 国家自然科学基金资助项目(30471248)
关键词 猪 开胃素A 下丘脑 免疫组织化学 pig orexin A hypothalamus immunohistochemistry
分类号 S852.1 [农业科学—基础兽医学]
  • 相关文献

参考文献12

  • 1雷治海.开胃素(Orexin)的研究进展[J].畜牧与兽医,2003,35(8):40-43. 被引量：11
  • 2Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors: a family of hypothatamic neuropeptides and G-protein-coupled receptors that regulate feeding behavior [J]. Cell, 1998, 92(4) : 573 ～ 585.
  • 3De Lecea L, KilduffT S, Peyron C, et al. The hypocretins : hypothalamus-specific peptides with neuroexcitatory activity [J]. Proc Nail Acad Sci USA, 1998, 95(1) : 322～327.
  • 4Preti A. Orexins (hypocretins) : Their role in appetite and arousal [ J ]. Current Opinion Investigational Drugs, 2002, 3 (8) : 1199 ～ 1206.
  • 5Kukkonen J P, Holmqvist T, Ammoun S, et al. Functions of the orexinergic/hypocretinergic system [ J ]. Am J Physiol Cell Physiol,2002, 283 : C1567 ～ 1591.
  • 6Kirchgessner A L. Orexins in the brain-gut axis [J]. Endocrine Reviews, 2002, 23:1 ～ 15.
  • 7Arihara Z, Takahashi K, Murakami O, et al. Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma [J]. Peptides, 2000, 21 : 565～570.
  • 8Cutler D J, Morris R, Sheridhar V, et al. Differential distribution of orexin-A and orexin-B immunoreactivity in the rat brain and spinal cord [J]. Peptide, 1999, 20: 1455～1470.
  • 9Iqbal J, Pompolo S, Sakurai T, et al. Evidence that orexin-containing neurons provide direct input to gonadotropin-releasing hormone neurons in the ovinc hypothalamus [J]. Neuroendocrinol, 2001, 13(12) : 1033 ～ 1041.
  • 10Ohkubo T, Tsukada A, Shamoto K. cDNA cloning of chicken orexin receptor and tissue distribution : sexually dimorphic expression in chicken gonads [ J ]. J Mol Endocrinol, 2003, 31 (3) : 499 ～ 508.

二级参考文献23

  • 1De Lecea L, Kilduff T S, Peyron C, et al. The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity [ J ]. Proc Nail Acad Sci USA, 1998, 95 : 322-327.
  • 2Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors:a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior [J]. Cell, 1998, 92: 573-585.
  • 3Kukkonen J P, Holmqvist T, Ammoun S, et al. Functions of the orexinergic / hypocretinergic system [ J ]. Am J Physiol cell Physiol, 2002, 283: C1567-C1591.
  • 4Preti A. Orexins (hypocretins) : Their role in appetite and arousal[J]. Current Opinion Investigational Drugs. 2002, 3 (8): 1199-206.
  • 5Samson W K and Resch Z T. The hypocretin/orexin story [ J ].Trends Endocrinol Metab, 2000, 11 : 257-262.
  • 6Dyer C J, Touchette K J, Carroll J A, et al. Cloning of porcine prepro-orexin cDNA and effects of an intramuscular injection of synthetic porcine orexin-B on feed intake in young pigs [ J]. Domest Anim Endocrinol, 1999, 16: 145-148.
  • 7Hungs M, Fan J, Lin L, et al. Identification and functional analysis of mutations in the hypocretin (orexin) genes of narcoleptic canines[J]. Genome Res, 2001, 11: 531-539.
  • 8Sakurai T, Moriguchi T, Fumya K, et al. Structure and function of human preproorexin gene [J]. J Biol Chem, 1999, 274: 17771-17776.
  • 9Waleh N S, Apte-Deshpande A, Terao A, et al. Modulation of the promoter region of preprohypocretin by alpha-interferon [ J ]. Gene,2001, 262: 123-128.
  • 10Lee J H, Bang E, Chae K J, et al. Solution structure of a new hypothalamic neuropeptide, human hypocretin-2/orexin-B [ J ]. Eur J Biochem, 1999, 266: 831-839.

共引文献10

同被引文献143

  • 1李庆梅,雷治海,陈敏,邓碧华,苏娟.开胃素A在猪一些器官内的分布[J].解剖学杂志,2005,28(3):290-291. 被引量：1
  • 2陈敏,雷治海,苏娟.兔脑内Orexin B免疫阳性神经元的分布定位[J].动物学杂志,2006,41(2):53-57. 被引量：3
  • 3陈敏,雷治海,苏娟.兔中枢神经内Orexin B免疫阳性神经纤维的分布[J].畜牧兽医学报,2006,37(8):819-823. 被引量：2
  • 4陈敏,雷治海,苏娟.兔脑和脊髓内开胃素A免疫阳性神经元和神经纤维的分布[J].南京农业大学学报,2006,29(4):102-106. 被引量：1
  • 5Arihara Z,Takahashi K,Murakami O,et al.Orexin-A in the human brain and tumor tissues of ganglioneuroblastoma and neuroblastoma.Peptides,2000,21:565 ～ 570.
  • 6Iqbal J,Pompolo S,Sakurai T,et al.Evidence that Orexin-containing neurons provide direct input to gonadotropin-releasing hormone neurons in the ovine hypothalamus.J Neuroendocrinol,2001,13(12):1 033～1 041.
  • 7Ohkubo T,Tsukada A,Shamoto K.cDNA cloning of chicken Orexin receptor and tissue distribution:sexually dimorphic expression in chicken gonads.J Mol Endocrinol,2003,31(3):499 ～ 508.
  • 8Ciriello J,Rosas-Arellano M P,Solano-Flores L P,et al.Identification of neurons containing Orexin-B (hypocretin-2)immunoreactivity in limbic structures.Brain Res,2003,967(1-2):123 ～ 131.
  • 9Galas L,Vaudry H,Braun B,et al.Immunohistochemical localization and biochemical characterization of hypocretin/Orexin-related peptides in the central nervous system of the frog Rana ridibunda.J Comp Neurol,2001,429 (2):242 ～252.
  • 10Alvin L B,Edward G J.The Thalamus and Basal Telencephalon of the Cat-A Cytoarchitectonic Atlas with Stereotaxic Coordinates.Wisconsin:the University of Wisconsin Press,1963.

引证文献7

二级引证文献9

南京农业大学学报
2005年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部