干扰素及白细胞介素2在轮状病毒胃肠炎中的动态变化

DYNAMIC CHANGES OF INTERFERON,INTERLEUkIN-2 RECEPTOR / INTERL-EUKIN-2 AND THEIR CLINICAL SIGNICANCEIN CHILDREN WITH ROTAVIRUS GASTRO-ENTERITIS

动态观察３０例轮状病毒（ＲＶ）胃肠炎患儿外周血单个核细胞，在ＲＶ体外诱导下干扰素（ＩＦＮ）、白细胞介素２（ＩＬ－２）、白细胞介素２受体（ＩＬ－２Ｒ）的变化，以及与疾病康复之间的关系。结果表明：在发病早期ＩＦＮ和ＩＬ－２淋巴因子可同时出现，但两者分泌高峰不同步，ＩＦＮ在急性期，ＩＬ－２在恢复期；腹泻恢复时间与ＩＬ－２Ｒ达高峰时间呈正相关（ｒ＝０．７４５７，Ｐ＜０．０１），与ＩＬ－２Ｒ水平呈负相关（ｒ＝０．５６８８，Ｐ＜０．０５）．提示：ＲＶ可激活机体ＩＦＮ和ＩＬ－２系统，两者相继在体液免疫之前达高峰，在ＲＶ胃肠炎的康复和保护机制中可能具有极其重要的作用。

AbstractWe dynamically observed in vitro rotavirus-induced interferon, interleukin-2 receptor / interleuk-in-2 respones of peripheral blood mononuclear cells inchildren with rotavirus gastroenteritis and their rela-tion to recovery of the illness. The results showed thatinter feron and interleukin-2 could be simultaneouslyelicited in early stage, but the peak phase of secretionwas not synchronous. The recovery time of diarrheahad positively correlated with the time of peak expres-sion of interleukin-2 receptor and negatively corre-lated with the expression level of interleukin-2receptor. These results suggest that eell mediated im-munity might play an important role in protection andrecovery from rotavirus infection.