巨细胞病毒性肝炎特异性IgG亚群检测及临床意义

DETECCTON OF IgG ANTIBODY SUBCL-ASSES TO CYTOMEGALOVIRUS IN PATIENTSWITH INFANTILE CYTOMEGAL OVIRUSHEPATITIS

对２１例婴儿巨细胞病毒性肝炎患儿（简称肝炎组）与１０例无症状巨细胞病毒感染婴儿（简称无症状组），应用ＥＬＩＳＡ方法进行抗巨细胞病毒（ＣＭＶ）ＩｇＧ亚群检测，肝炎组中１３例做了恢复期的复查。结果表明，肝炎组抗ＣＭＶＩｇＧ＿２、ＩｇＧ＿４值均为较低水平，无症状组抗ＣＭＶＩｇＧ＿１、ＩｇＧ＿３，值明显高于肝炎组；肝炎组恢复期抗ＣＭＶＩｇＧ＿３明显增高，而抗ＣＭＶＩｇＧ＿１增高不显著。提示体液免疫反应特别是抗ＣＭＶＩｇＧ＿３在抗ＣＭＶ感染中起到一定作用，对ＣＭＶ感染高危婴幼儿可考虑应用含高滴度抗ＣＭＶ抗体的免疫球蛋白。

AbstractBy using enzyme-linked immunosorbent assay(ELISA), sera from 21 cases of infantile cytomegalovirus hepatitis (ICH) and cases of asymptomaticCMV infeetions (ACI) were tested for anti-CMVantibodies of IgG subelasses. CMV-speci- fic IgG2and IgG4 values were very low in both groups.CMV-specific IgG1 and IgG3 levels in ACI groupwere higher than thosc in ICH group. Duringconvalescence, 13 cases with ICH showed a significantincrease in CMV-specific IgG3, but no significant in-crease in CMV-specific IgG1, IgG2 and IgG4 wasfound. These results suggest that CMV-specificantibodies, especially IgG3 may play a role in defenceagainst CMV infection.