盐亭县核黄素强化盐干预试验人群肿瘤发病情况

An Analysis of Cancer Incidence Among Riboflavin Fortified Salt Intervention Residents in Yanting, China

[目的]探讨核黄素强化盐干预试验对人群肿瘤发病率的影响。[方法]对盐亭县核黄素强化盐干预试验人群干预期(1992～1996)和干预停止期(1997～2001)的肿瘤发病资料进行分析。[结果]试验组男性食管癌、肺癌、结直肠癌,女性食管癌、白血病、宫颈癌发病率在干预期高于对照组,而在干预停止期低于对照组。两组人群10年的肿瘤发病资料比较,试验组除胃癌外其他肿瘤发病率均低于对照组,尤其是食管癌和宫颈癌发病率明显低于对照组,而两组人群中肺癌、结直肠癌发病率都上升,但试验组的上升幅度低于对照组。[结论]试验组与对照组肿瘤发病率的差异,提示补充核黄素有利于降低肿瘤的发病风险,值得在更大范围的肿瘤高危人群中推广。

Purpose] To investigate the effect on cancer incidence in Riboflavin Fortified Salt Intervention population. [Methods] The cancer incidence of the population with Riboflavin Fortified Salt Intervention during the intervention period (1992~1996) and the period after intervention (1997~2001) were analyzed.[Results]The incidence rates of esophageal cancer, lung cancer and colorectal cancer for male, esophageal cancer, leukemia and cervical cancer for female among the intervention population were higher than those in control group during the intervention period, while they were lower than that in control group during the period after intervention. Compared with control group, lower incidence rates of all the other cancers except for stomach cancer were observed among the trial group in the period after intervention, especially for esophageal cancer and cervical cancer. Although the increase incidence of lung cancer and colorectal cancer were observed between both groups. A less extent of increase was found among the trial group than that in control group. [Conclusion] The difference of incidence in trial group and control group suggests that supplement of riboflavin might decrease the cancer risk, it is worthy extending for a large scale of high risk population.