利培酮与氯氮平治疗老年精神分裂症疗效分析

Analysis on Senile Dementia Praecox Treated with Risperdone Clozapine

目的了解利培酮与氯氮平治疗老年精神分裂症的效果及不良反应是否存在差异。方法将40例年龄≥60岁的老年期精神分裂症病人随机分为两组(不分性别),每组20例,一组服用利培酮,一组服用氯氮平,经一段时间的观察和简明精神病评定量表(BPRS)的变化、副反应量表(TESS)的检测,评定两组药物的疗效和副反应。结果利培酮与氯氮平对老年精神分裂症的疗效无差异,但不良反应利培酮较氯氮平轻,且相对安全,服从性高、易于接受。结论利培酮是老年精神分裂症患者选用的有效且安全的药物之一。

Objective To discuss the curative effect and side effect of senile dementia praecox with risperdone and clozapine and their difference. Methods 40 cases dementia praecox patients over 60 were divided into 2 groups randomly 20 cases per each. One group was given riperdone and other was given clozapine. The BPRS and TESS were detected and assess their effects. Results There was no significant difference between risperdone and clozapine to treat senile dementia praecox but riperdone had slight side effect with safety and acceptable.conclusion Risperdone might be a safe drug to treat senile dementia praecox.